New Discovery Hold Promise for Transplant and HIV+ Patients

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A team of researchers at University of British Columbia lead by Dr. William Jefferies announced that they have discovered the mechanism which activates T-Cells, the white blood cells that kill viruses and can cause transplant organ rejection.
In the August edition of Immunity, the on-line research journal, Jeffries team announced finding which may lead to new drug development.
“By identifying the mechanism that leads T-cells to spring into action and proliferate, the research… provides a new target for future or existing drugs that could bolster the immune systems of people with HIV or cancer,” Researchers said in an interview with Science Daily.
This is one of the latest advances in medical research that is changing the treatment options for patients with HIV as well as those who need transplants. The discovery of this mechanism could be manipulated to help prevent the rejection of transplant organs due to attacks by the bodies’ immune system. In medications for organ transplant patients new medications could limit immune system reactions that cause rejection by attacking new organ. Jeffries also suggested that this discovery might allow for new medications for disease where the immune system attacks healthy tissue. This could improve treatment of other autoimmune diseases like arthritis and diabetes.
Jefferies collaborated with Simon V. Hunt, Oxford University, and Professor Torben Bech-Hansen at the University of Calgary. The team at UBC included Professors David Fedida, Rusung Tan, and Hung-Sia Teh, Associate Professor Douglas Waterfield, graduate students Kyla Omilusik, Yiwen Teresa Wang and Xiaoxi Chen and research associates John Priatel and Hongjian Xu.
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