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Sunday, December 15, 2013

Pelvic Congestion Syndrome and Chronic Pelvic Pain


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Somewhere around 30 % of women experience chronic pelvic pain, defined as pin below the belly button lasting for 6 months of longer.  One of the causes of this sort of pain can be Pelvic Congestion Syndrome.
Pelvic Congestion Syndrome develops when blood flow in veins in the lower abdomen stop working correctly. In normally functioning veins, blood flows in only one direction. When the valves are defective or injured, blood starts to flow backwards.  This causes pooling of blood in the veins, forcing the walls out and making the veins bigger. It is believed that these varicose veins when located near nerves cause pain.

This condition is difficult to diagnose because these internal varicose veins are internal. They are not visible on physical exam, or on ultra sound examinations. To diagnose this condition your doctor may need to inject contrast dye into the veins through a catheter  - a process called a veinogram. 
Once the varicose veins are located and the condition is diagnosed the doctor may discuss several different treatments.

Drug Treatments: Drug treatments have been less then successful on most cases. There has been success with the use of antidepressants in treating this condition because they help reduce pain and help treat the depression and frustration which being on chronic pain can cause. If your doctor recommends this keep and open mind. They are not saying you are crazy or dismissing your pain. They are seriously trying to treat your condition.  

Minimally Invasive Surgical Treatment: The most common and most effective treatment for Pelvic Congestion Syndrome is Transcatheter Pelvic Vein Embolization. Embolization involves blocking the blood flow in the problematic vein(s), allowing shrinkage and relief of symptoms. This procedure can be done as an outpatient procedure or patients may be observed over night at the hospital. Either way, recover is usually quick and patients resume normal activities within days. Women experience high levels of pain reduction within 6 months in 50% to 80% of cases.
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Friday, December 13, 2013

Pathway to New to Breast Cancer Treatment Announced



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Duke University researchers announced that targeting a protein in the nucleus of breast cancer cells, called ERRa, which plays a part in growth of aggressive tumors, may lead the way to a new breast cancer treatment.

These findings published in the Oct. 18, 2011, issue of the journal Cancer Cell, presents a potential new way to inhibit breast cancer growth among the particularly lethal estrogen receptor negative cancers which do not respond to available hormone therapies.

In an interview with Science Daily, Donald McDonnell, PhD the chairman of the Duke Department of Pharmacology and Cancer Biology stated “This is validation of a new drug target for a subset of breast cancers that have poor treatment options.”

"There are a lot of proteins that play important roles in breast cancer pathogenesis, but disappointingly, the activity of only a few of these proteins can be inhibited by drugs," McDonnell said. "In contrast, it's relatively easy to interfere with ERRα's function. So instead of looking for the pathways that lead to ERRα activation, we can aim directly at the target ERRα. It doesn't matter what's upstream."

McDonnell said the new drug approach could be applied to many cancers including colon and ovarian cancers, since ERRα is highly active in many different malignancies.
"The initial excitement is we have found a target that seems to be important for estrogen-negative cancers," McDonnell said.

The Duke University research team is now investigating the reason why higher ERRα activity results in more aggressive breast cancer tumors. The researchers are also helping develop new drugs to inhibit the activity of this receptor.
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Wednesday, December 11, 2013

Ovarian Cancer: Early Detection is Key



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Ovarian Cancer affects one in 70 women.
It kills 14,000 women in the U.S. each year, and while considered relatively rare has a low rate of survival. It was previously called the “Silent Killer” because most women are not diagnosed until the cancer has progressed to an advanced stage that no longer responds well to treatment.

Late detection happened primarily because the ovaries are embedded deep in the body, tumors emerging in that organ are difficult to detect, either by physical examination or even by more sophisticated molecular methods.

The good news is that early detection is becoming a little easier and when the disease is caught early the 5 year survival rate raises 30% to 90%. The Key seems to be constant vigilance by women and their doctors.

Last year physicians from MD Anderson began tracing healthy women through annual blood tests for CA125 level changes in blood work. Rising levels of CA125 are known to be associated with ovarian tumor growth. Unfortunately, even this test is inconclusive on its own because levels can change due to benign conditions such as pregnancy, endometriosis and fibroids. Tracking changes annually has become one way to sort out women who should be more closely screened for ovarian cancer along with family histories of cancer and previous cancers in different locations

Northwestern Memorial announced recently that added to doctor vigilance patients can participate by tracking a specific set of symptoms associated with Ovarian Cancer.

"The best scenario would be to prevent this cancer entirely but until that day comes women need to focus on good health behaviors, listen to their bodies and know their family history" according to Diljeet Singh, MD, gynecological oncologist and co-director of the Ovarian Cancer Early Detection and Prevention Program at Northwestern Memorial Hospital.

Early warning signs which include:
  • Bloating
  • Pelvic or abdominal pain
  • Difficulty eating or feeling full quickly
  • Urinary symptoms (urgency or frequency)
  • Increased abdominal size (pants getting tighter around waist)
Singh comments that the frequency and number of symptoms is important.  Women who experience a combination of these symptoms almost daily for two to three weeks should see their doctor. While these symptoms mimic other possible medical conditions

Although it is unclear what causes ovarian cancer factors that increase the odds of developing the disease include carrying a mutation of the BRCA gene, having a personal history of breast cancer or a family history of ovarian cancer, being over the age of 45 or if a woman is obese. Doctors recommend screenings for women with these factors begin at age 20 to 25, or five to 10 years earlier than the youngest age of diagnosis in the family. In addition, there are genetic tests available that can identify women who are at a substantially increased risk.

Women at higher risk categories many choose to make medical and lifestyle decisions which can improve their odds of avoiding Ovarian Cancer. Those who use birth control pills for five years or more are three-times less likely to develop ovarian cancer. Also permanent forms of birth control such as tubal ligation have been found to reduce the risk of ovarian cancer by 50 percent. In cases where women have an extensive family history of breast or ovarian cancer, or who carry altered versions of the BRCA genes, may receive a recommendation to remove the ovaries and fallopian tubes. While clearly a radical option this lowers the risk of ovarian cancer by more than 95 percent.

"Eating a diet rich in fruits and vegetables, getting regular exercise, maintaining a normal body weight and managing stresses are all ways women can help decrease their risk of ovarian cancer," added Singh.
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Saturday, December 7, 2013

New York Abortion Access Fund – Support for Women deserves Our Support



“What am I going to DO?!” is a question that reproductive health educators hear every day when it comes to the question of paying for abortion service. Unfortunately, it is not always and easy answer. 
In New York we are one of the lucky thirteen states where Medicaid covers abortion services. However, the maximum income allowed to qualify for Medicaid is extremely low.  Even if they make more than this limit, women are often barely scraping by prior to the added expense of an unplanned pregnancy.
Even if you are insured there are no guarantees. If you have commercial health insurance, depending on your companies plan, you may not be covered for abortion services. For example Federal Employees are not covered for abortion services because government plans do not provide for abortion care.
This puts even insured women and families in the awkward position of having to plan for unplanned pregnancies. With the cost of an abortion raging from five hundred to several thousand dollars, covering this type of payment may be out of reach.
But for women who fall through these cracks there is still hope! Founded in 2001, The New York Abortion Access Fund is a grassroots organization started to give concrete help to low income women from New York, or coming to New York, for abortion services.
This non-profit organization, supported completely through private tax deductible donations and volunteer work, takes calls from all over the country from women who are in financial need. They are part of a larger grassroots movement to help women centered in the National Network of Abortion Funds.
 Just this week, NYAAF pledged funds to a woman who made just a little bit too much money to qualify for Medicaid coverage but did not have enough money to afford her abortion.
“There are thousands of women that fall through the cracks. Women who aren’t eligible for Medicaid, or who have health care plans that don’t cover it. Women who need abortion care and simply can’t afford it,” according to Eesha Pandit, NYAAF board member.
“NYAAF is here to help these women. In 2010 our clients ranged from an 11-year-old victim of sexual assault to a 43-year-old mother of four. NYAAF has made grants to women of all ethnicities, their average age is 25, and four out of ten are already parents.” Pandit said.
Using creative approaches to fundraising, such as Cocktail Parties, Dinner Parties, Art Show, Theatrical Performances and participation in the National Bowl-a-thon NYAAF has provided tens of thousands of dollars to women in need over the past 10 years.

Pledges from NYAAF often mean the difference between women receiving services - or being turned
away for lack of funds. These direct donations have helped make sure that abortion services does not become restricted, not through legal channels, but through economic limitations.
If you are interested in participating in the support of low income women’s rights to reproductive health and self determination contact NYAFF by e-mail at nyaaf@nnaf.org or by phone at (212) 252- 4757. Donations are also accepted by mail to:
New York Abortion Access Fund
FDR Station Box 7569
New York NY 10150

Wednesday, December 4, 2013

New Protein May Lead to New Breast Cancer Treatments



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A New Approach may be around the corner for the treatment of breast cancer.

New research published September 14, 2011 online in the Journal of the National Cancer Institutejust announced that Dr. Suresh Alahari, the Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans and its Stanley S. Scott Cancer Center, has found that a protein discovered by his laboratory can inhibit the growth of breast cancer cells.
“Our research shows that nischarin (the newly discovered protein) can function as a tumor suppressor of breast cancer, inhibiting breast cancer progression," Dr Alahari said in a interview with Science Daily.
This marks a significant advance in the battle against one of the disease most likely to effect women and some men during their life time. The American Cancer Society estimates that for 2011:
  • About 230,480 new cases of invasive breast cancer will be diagnosed in women.
  • About 57,650 new cases of carcinoma in situ (CIS) will be diagnosed (CIS is non-invasive and is the earliest form of breast cancer).
  • About 39,520 women will die from breast cancer
The LSUHSC research team supported by grants from the NIH, Susan Komen Foundation and Louisiana Cancer Research Consortium included Dr. Robin McGoey, postdoctoral fellows, Drs. Somesh Baranwal, Yanfang Wang, Rajamani Rathinam, and Lianjin Jin. Researchers from Duke University and Memorial Sloan Kettering Cancer Center also contributed.
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